To watch this film, you need to step over yourself to some extent, because most of it takes place in, so to speak, Cartoon Town, which is populated by simply indescribable freaks. You need to immediately tune in to the arthouse mode, I noticed, for example, how two live actors had to play alone on an empty stage with cardboard scenery, so that they then drew all the other participants, and the actors almost coped. Speaking of cardboard, I think it was done on purpose, not because they couldn't do the full overlay like in Roger Rabbit. Rabbit is a children's film, and this one is still for adults, and the authors probably wanted to leave a message to the viewer "Guys, we all understand, we are not idiots, look, we actually have a theater here." A deliberate negligence, at least that's how I see it.
About the plot. I can’t believe that a comic book about such an ugly world could be popular, it is too ridiculous even by the standards of all cartoons. A living person would not survive in the world of cartoons, because he is extremely traumatic: the locals all the time blow each other up, beat with sledgehammers, but they are immortal cartoons, and the first joke will simply kill a person. And the hero of Brad Pitt there not only survives, but is an authority. Who exactly is he? Behaving like an FBI agent, so it involves working for some serious structure, and what serious structure can there be in this world of schizophrenia? He has lived there for 50 years, he has a girlfriend, and he has never made love to her. How is that even possible? In the end, the characters are busy sharing an incomprehensible McGuffin - what is the spike? Where did this object come from, how did it work, how did it get into the building? It looks like two-thirds of the film was shot without knowing what it was about, and only in the end decided to get out of this artifact.
In general, the merit of the film is only that it is, it is almost unique in its style. But if there were a whole genre of such films / cartoons, then this one would lose to them without a doubt. Rabbit to Roger is definitely losing.